cytotoxic flavonoid glycosides from rapistrum rugosum l.
نویسندگان
چکیده
five flavonoid glycosides were isolated from the n-butanol soluble fraction of the ethanolic extract of rapistrum rugosum and their structures were assigned from 1h- and 13c-nmr spectra (dept) with 2d nmr as quercetin-3-o-α-l-rhamnopyranoside (1), quercetin-3-o-β-d-xyloside (2), quercetin, 3-o-α-l-arabinopyranoside,7-o-α-l-rhamnopyranoside (3), kaempferol 3-o-α-l-arabinopyranoside, 7-o-α-l-rhamnopyranoside (4) and rutin (5). the srb cytotoxic assay was used to investigate the antitumor activities of n-butanol extract, compound 3 and its hexaacetate 3a, for the first time. compounds 3 and 3a showed cytotoxic activity against the human cancer cell line, namely, hepg2 (hepatocellular carcinoma cell line) with ic50 (concentration of compound required to reduce cell survival by 50%) 0.86 µg/ml and 3.50 µg/ml, respectively. these results proved that compound 3, the major flavonoid of the n-butanol soluble fraction, has significant cytotoxic activity compared with the standard antitumor drug doxorubicin (0.60 µg/ml).
منابع مشابه
Cytotoxic Flavonoid Glycosides from Rapistrum rugosum L.
Five flavonoid glycosides were isolated from the n-butanol soluble fraction of the ethanolic extract of Rapistrum rugosum and their structures were assigned from (1)H- and (13)C-NMR spectra (DEPT) with 2D NMR as quercetin-3-O-α-L-rhamnopyranoside (1), quercetin-3-O- β-D-xyloside (2), quercetin, 3-O-α-L-arabinopyranoside,7-O-α-L-rhamnopyranoside (3), kaempferol 3-O-α-L-arabinopyranoside, 7-O-α-L...
متن کاملCytotoxic Flavonoid Glycosides from Rapistrum rugosum L.
Five flavonoid glycosides were isolated from the n-butanol soluble fraction of the ethanolic extract of Rapistrum rugosum and their structures were assigned from 1H- and 13C-NMR spectra (DEPT) with 2D NMR as quercetin-3-O-α-L-rhamnopyranoside (1), quercetin-3-O-β-D-xyloside (2), quercetin, 3-O-α-L-arabinopyranoside,7-O-α-L-rhamnopyranoside (3), kaempferol 3-O-α-L-arabinopyranoside, 7-O-α-L-rham...
متن کاملCytotoxic Flavonoid Glycosides from Rapistrum rugosum L.
Five flavonoid glycosides were isolated from the n-butanol soluble fraction of the ethanolic extract of Rapistrum rugosum and their structures were assigned from 1H- and 13C-NMR spectra (DEPT) with 2D NMR as quercetin-3-O-α-L-rhamnopyranoside (1), quercetin-3-O-β-D-xyloside (2), quercetin, 3-O-α-L-arabinopyranoside,7-O-α-L-rhamnopyranoside (3), kaempferol 3-O-α-L-arabinopyranoside, 7-O-α-L-rham...
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tribulus terrestris l. var. orientalis (kerner) g. beck is widely used in the traditional medicine of many countries. several flavonoides are identified from the plant material. aerial parts which collected from northeast of iran are used in this study. three flavonoid glycosides were isolated and characterized. the flovonoids were found to be based on quercetin and kaempferol. flavonoid glycos...
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عنوان ژورنال:
the iranian journal of pharmaceutical researchجلد ۱۱، شماره ۳، صفحات ۸۳۹-۸۴۴
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