cytotoxic flavonoid glycosides from rapistrum rugosum l.

نویسندگان

areej mohamed al-taweel department of pharmacognosy, college of pharmacy, king saud university, riyadh, kingdom of saudi arabia.

ghada ahmed fawzy 1-department of pharmacognosy, college of pharmacy, king saud university, riyadh, kingdom of saudi arabia. 2-department of pharmacognosy, faculty of pharmacy, cairo university, cairo 11562, egypt.

shagufta perveen department of pharmacognosy, college of pharmacy, king saud university, riyadh, kingdom of saudi arabia.

چکیده

five flavonoid glycosides were isolated from the n-butanol soluble fraction of the ethanolic extract of rapistrum rugosum and their structures were assigned from 1h- and 13c-nmr spectra (dept) with 2d nmr as quercetin-3-o-α-l-rhamnopyranoside (1), quercetin-3-o-β-d-xyloside (2), quercetin, 3-o-α-l-arabinopyranoside,7-o-α-l-rhamnopyranoside (3), kaempferol 3-o-α-l-arabinopyranoside, 7-o-α-l-rhamnopyranoside (4) and rutin (5). the srb cytotoxic assay was used to investigate the antitumor activities of n-butanol extract, compound 3 and its hexaacetate 3a, for the first time. compounds 3 and 3a showed cytotoxic activity against the human cancer cell line, namely, hepg2 (hepatocellular carcinoma cell line) with ic50 (concentration of compound required to reduce cell survival by 50%) 0.86 µg/ml and 3.50 µg/ml, respectively. these results proved that compound 3, the major flavonoid of the n-butanol soluble fraction, has significant cytotoxic activity compared with the standard antitumor drug doxorubicin (0.60 µg/ml).

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Cytotoxic Flavonoid Glycosides from Rapistrum rugosum L.

Five flavonoid glycosides were isolated from the n-butanol soluble fraction of the ethanolic extract of Rapistrum rugosum and their structures were assigned from (1)H- and (13)C-NMR spectra (DEPT) with 2D NMR as quercetin-3-O-α-L-rhamnopyranoside (1), quercetin-3-O- β-D-xyloside (2), quercetin, 3-O-α-L-arabinopyranoside,7-O-α-L-rhamnopyranoside (3), kaempferol 3-O-α-L-arabinopyranoside, 7-O-α-L...

متن کامل

Cytotoxic Flavonoid Glycosides from Rapistrum rugosum L.

Five flavonoid glycosides were isolated from the n-butanol soluble fraction of the ethanolic extract of Rapistrum rugosum and their structures were assigned from 1H- and 13C-NMR spectra (DEPT) with 2D NMR as quercetin-3-O-α-L-rhamnopyranoside (1), quercetin-3-O-β-D-xyloside (2), quercetin, 3-O-α-L-arabinopyranoside,7-O-α-L-rhamnopyranoside (3), kaempferol 3-O-α-L-arabinopyranoside, 7-O-α-L-rham...

متن کامل

Cytotoxic Flavonoid Glycosides from Rapistrum rugosum L.

Five flavonoid glycosides were isolated from the n-butanol soluble fraction of the ethanolic extract of Rapistrum rugosum and their structures were assigned from 1H- and 13C-NMR spectra (DEPT) with 2D NMR as quercetin-3-O-α-L-rhamnopyranoside (1), quercetin-3-O-β-D-xyloside (2), quercetin, 3-O-α-L-arabinopyranoside,7-O-α-L-rhamnopyranoside (3), kaempferol 3-O-α-L-arabinopyranoside, 7-O-α-L-rham...

متن کامل

Flavonoid Glycosides from Tribulus terrestris L. orientalis

      Tribulus terrestris L. var. orientalis (Kerner) G. Beck is widely used in the traditional medicine of many countries. Several flavonoides are identified from the plant material. Aerial parts which collected from northeast of Iran are used in this study. Three flavonoid glycosides were isolated and characterized. The flovonoids were found to be based on quercetin...

متن کامل

flavonoid glycosides from tribulus terrestris l. orientalis

tribulus terrestris l. var. orientalis (kerner) g. beck is widely used in the traditional medicine of many countries. several flavonoides are identified from the plant material. aerial parts which collected from northeast of iran are used in this study. three flavonoid glycosides were isolated and characterized. the flovonoids were found to be based on quercetin and kaempferol. flavonoid glycos...

متن کامل

Flavonoid glycosides from Cassia alata.

Two new glycosides, chrysoeriol-7-O-(2"-O-beta-D-mannopyranosyl)-beta-D-allopyranos ide and rhamnetin-3-O-(2"-O-beta-D-mannopyranosyl)-beta-D-allopyranosid e, were isolated from the seeds of Cassia alata. The structures were established on the basis of chemical evidence and spectroscopic methods, especially NMR.

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
the iranian journal of pharmaceutical research

جلد ۱۱، شماره ۳، صفحات ۸۳۹-۸۴۴

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023